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Developmental toxicity of arsenic: a drift from the classical dose–response relationship

The developmental toxicity of the low-level exposure to arsenic and other toxic metals is a significant concern in large parts of the world. Unlike acute toxic exposure, the classical dose–response relationship is not adequate for estimating the possible impact of chronic low-level arsenic exposure. The real-life risk and impact assessments require the consideration of the co-exposure to multiple toxins, individual genetic and nutritional predisposition, and the particularly vulnerable stages of the neurodevelopment.


This context shifts the assessment model away from the ‘one-exposure-for-one-health-effect.’ We underscore the need for a comprehensive risk assessment that takes into account all relevant determinants. We aim to elaborate a model that can serve as a basis for an understanding of complex interacting factors in a long-lasting and ongoing low-level arsenic exposure, to identify, protect, and support the children at risk.


Bjørklund, G., Tippairote, T., Rahaman, M. S., & Aaseth, J. (2019). Developmental toxicity of arsenic: a drift from the classical dose–response relationship. Archives of Toxicology. doi:10.1007/s00204-019-02628-x


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