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1.1. Exposomics : exploring the health consequences of host-environment homeodynamic interactions

The exposome explores the biomarkers of all exposures in an individual and their relevance to human health. External exposomes may derive from the diet, microbes, environmental toxins, or prescribed medications, while internal exposures are nutrients, cellular mediators, hormones, metabolic intermediates, reactive products, and various biomolecules. Exposomics applies big-data technologies to find the associations between exposures, the effect of exposures, and other disease susceptibilities such as genetic predisposition and individual metabolic status. Therefore, this innovative field encompasses genomics, metabolomics, lipidomics, proteomics, adductomics, and transcriptomic.


The evidence of various exposures in humans suggests the ongoing interactions between hosts to their lifestyle and environment. The continual fluctuation in these measurements also defies the conventional hemostasis model. The homeodynamic host-environment interactions correlate various exposures to individual host responses and health consequences. The exposomics, thus, signify the mutual relationships between the inner and outer worlds of humans.


Rappaport, S.M.; Barupal, D.K.; Wishart, D.; Vineis, P.; Scalbert, A. The blood exposome and its role in discovering causes of disease. Environ Health Perspect 2014, 122, 769-774, doi:10.1289/ehp.1308015.


Ding, E.; Wang, Y.; Liu, J.; Tang, S.; Shi, X. A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases. Human Genomics 2022, 16, 54, doi:10.1186/s40246-022-00428-6.


Price, E.J.; Vitale, C.M.; Miller, G.W.; David, A.; Barouki, R.; Audouze, K.; Walker, D.I.; Antignac, J.-P.; Coumoul, X.; Bessonneau, V.; et al. Merging the exposome into an integrated framework for “omics” sciences. iScience 2022, 25, 103976, doi:https://doi.org/10.1016/j.isci.2022.103976.



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