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An Individualized Nutritional Recommendations to Reduce Hb A1c, Medication Uses, and Weight in T2D

We evaluated whether individuals with Type 2 diabetes (T2D) could be taught to sustain

adequate carbohydrate restriction to achieve nutritional ketosis as part of a comprehensive intervention.


After 10 weeks, HbA1c level was reduced by 1.0% (SD 1.1%; 95% CI 0.9% to 1.1%, P<.001), and the percentage of individuals with an HbA1c level of <6.5% increased to 56.1% (147/262). 133/234 (56.8%) individuals had one or more diabetes medications reduced or eliminated by 10 weeks. Mean body mass reduction was 7.2% (SD 3.7%; 95% CI 5.8% to 7.7%, P<.001) from baseline (117, SD 26, kg). Mean BOHB over 10 weeks was 0.6 (SD 0.6) mmol·L−1 indicating consistent carbohydrate restriction.


These initial results indicate that an individualized program delivered and supported remotely that incorporates nutritional ketosis can be highly effective in improving glycemic control and weight loss in adults with T2D while significantly decreasing medication use.


McKenzie AL, Hallberg SJ, Creighton BC, Volk BM, Link TM, Abner MK, Glon RM, McCarter JP, Volek JS, Phinney SD: A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes. JMIR diabetes 2017, 2(1):e5.



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