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Major Doubt Cast on Amyloid Hypothesis in Alzheimer's Disease!

A landmark 2006 Alzheimer’s research paper, suggesting amyloid beta (Aβ*56) as a cause of memory impairment, is set to be retracted due to doctored images. The senior author, Dr. Karen Ashe, acknowledges manipulated figures but stands by the conclusions. This paper, cited nearly 2500 times, has driven much of the amyloid-targeted Alzheimer's research and drug development.


With the retraction, serious doubts arise about the amyloid hypothesis, long a dominant theory in Alzheimer's research. Some scientists now question the very existence of Aβ*56. This controversy underscores the urgent need for independent investigations into research integrity, free from conflicts of interest.


The Alzheimer's research community remains divided, especially in light of the recently approved antiamyloid drug Leqembi, which modestly slows cognitive decline but comes with significant risks.


However, there is hope on the horizon! Despite these setbacks, several upcoming reports highlight the effectiveness of personalized lifestyle management protocols in reversing cognitive decline. These promising approaches could reshape the future of Alzheimer’s treatment.


doi: 10.1126/science.zdo1zpb

Lesné, S., Koh, M., Kotilinek, L. et al. A specific amyloid-β protein assembly in the brain impairs memory. Nature 440, 352–357 (2006). https://doi.org/10.1038/nature04533




 

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