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When the Skin Remembers: How Everyday Exposures Strengthen Our Defenses
A new review in eLife by Gres et al. (2025) , “Trained Immunity in Skin Infections: Macrophages and Beyond,” offers a fascinating...
Oct 113 min read


🔁 Rhythm and Fuel: How Two Complementary Models Explain Your Body’s Hidden Metabolic Struggles
The CACH and ERM frameworks reveal why resilience isn’t just about stress or rest — it’s about the tempo and the resources to sustain it....
Jul 223 min read


GAS, ISRmt, and the Immune System: A Unified Model of Exercise Stress
New insights from Krüger et al. (2019) in Deutsche Zeitschrift für Sportmedizin show how exercise immunology mirrors classic stress...
Mar 221 min read


Immune Repair as a Stress Response: The Hidden Energy Cost
Just like Selye’s General Adaptation Syndrome (GAS) —alarm, resistance, exhaustion—the immune system follows a similar arc: ⚔️ Alarm =...
Mar 211 min read


The ACEs Paradox: Why Stress Affects Some More Than Others
A 2021 JAMA Pediatrics study by Baldwin et al. challenges the idea that adverse childhood experiences (ACEs) directly predict individual...
Mar 172 min read


Stress, Signals, and Survival: The Role of Mitochondrial ISR in Systemic Adaptation
Mitochondria are not just powerhouses; they are command centers , orchestrating cellular stress responses and systemic adaptation through...
Dec 2, 20241 min read


Cold Exposure Induces Epigenetic Modifications Beneficial for Long-Term Health
A recent study on mice shows that short-term cold exposure can induce long-lasting health benefits through persistent epigenetic...
Jun 18, 20241 min read
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