A new perspective from neuroscience is reshaping how we understand stress and mental illness — not as a chemical imbalance , but as an energetic imbalance . A recent paper in Neuroscience & Biobehavioral Reviews   by Kelley and colleagues (2025) introduces the Allostatic Triage Model of Psychopathology (ATP)  — a unifying theory that sees the brain as an energy-allocating organ. Under stress, it must decide which functions get powered and which are temporarily “dimmed” to con

🧪 A Groundbreaking Study That Deserves Attention A recent human study published in JCI Insight  (Ryan et al., 2024) has revealed something quietly unsettling: high-dose atorvastatin — one of the most commonly prescribed statins in the world — progressively impairs mitochondrial function  in skeletal muscle, even in healthy adults. Over just 56 days of 80 mg atorvastatin therapy, the researchers observed: A >30% decline in mitochondrial respiratory capacity  in muscle biopsie

Our immune system is brilliant at responding to threats. When infection or injury strikes, immune cells spring into action—mobilizing energy, nutrients, and molecular machinery to protect us. But even the strongest defense system has limits. What happens when the immune system stays “switched on” for too long? A new study published in JCI Insight  by Amir Yousif and colleagues (2025)  offers a clear answer. Using an advanced lab model, the researchers showed how prolonged im

Every living cell is powered by a complex network of reactions that turn nutrients into usable energy. In their recent paper, Energy Metabolism in Health and Diseases , Liu and colleagues deliver an impressive tour through this landscape—showing how energy pathways such as glycolysis, fatty-acid oxidation, and mitochondrial respiration underpin health and, when disrupted, drive disease. The review’s strength lies in its mechanistic depth . It traces how mitochondrial damage,

We often think of mitochondria as tiny “powerhouses” that churn out energy. But recent research shows they’re far more than miniature batteries — they are decision-making hubs that control how the body responds to stress, how it ages, and whether it ultimately repairs or unravels. Two new scientific papers bring this idea into sharp focus. One, published in Aging , examined the proteins inside mitochondria that determine when a cell remains resilient or slips into senescenc

A new review in eLife  by Gres et al. (2025) , “Trained Immunity in Skin Infections: Macrophages and Beyond,”  offers a fascinating...

In 2025, Martin Picard and Ramaswamy Murugan published a groundbreaking perspective in Cell Metabolism  introducing the Energy Resistance Principle (ERP) . They proposed that life itself is a process of energy transformation through resistance —a delicate balance between energy potential, flow, and constraint. Inside every cell, electrons move from food to oxygen through the mitochondrial respiratory chain, driving ATP production. But this flow is never free: mitochondria i

When we think of the immune system, most of us picture an army: white blood cells attacking viruses, antibodies neutralizing invaders,...

For more than a century, scientists have been fascinated by the microbes in our gut. In the early 1900s, Nobel laureate Elie Metchnikoff ...

A new study published in the Journal of Applied Physiology  (Kashi et al., 2025) has uncovered something many of us overlook: how much...

For years, nutritional advice in cardiology has followed a simple script: eat less, cut calories, and reduce salt.  This advice was...

A new review in Trends in Endocrinology & Metabolism  (Shangguan et al., 2025) explores why our immune soldiers — CD8+ T cells  — so...

A new review in The Lancet Diabetes & Endocrinology   (Hofbauer et al., 2025) takes a deep dive into a problem that doctors have...

When most people think about nutrition, one word comes to mind: calories . For decades, medical and dietary advice has been shaped by the...

For decades, low- and no-calorie sweeteners (LNCS) — the aspartames, saccharins, and sugar alcohols of the world — have been sold as the...

When we think about the brain, we often picture it as a powerful computer—processing, storing, and retrieving information. But a...

September 2025 In the age of viral headlines and fear-based nutrition advice, one common myth just won’t die: “ High protein diets,...

Have you ever felt stuck in a cycle of unexplained symptoms? Maybe fatigue, digestive issues, or persistent pain that just won’t go away?...

A 2022 paper in the Journal of Clinical Endocrinology & Metabolism  (Téblick, Gunst, & Van den Berghe, 2022) revisits a long-debated...

A new study in BMC Infectious Diseases  (Feng et al., 2025)  has shed light on the prognostic value of the stress hyperglycemia ratio...