Recent research introduces an intriguing twist in lipid theory through an n-of-1 study on a unique Lean Mass Hyper-Responder (LMHR) — an individual with a rare metabolic response that results in very high LDL levels on a ketogenic diet. This study, with a carefully controlled crossover design and appropriate wash-out period, revealed a stunning 71% reduction in LDL by adding an unexpected carb source: Oreo cookies! Surprisingly, this drop was more effective than high-intensity statins for this participant.
The study suggests that the Oreo intervention may align more naturally with the body’s physiology. By replenishing glycogen, the carbohydrates help the body reduce LDL production in a way that fits the "Lipid Energy Model," which posits that the liver increases LDL production to transport energy when carbs are low. Statins, by contrast, work against this physiological process, reducing LDL by blocking protein involved in cholesterol production that may not align as closely with the body’s energy needs in low-carb states.
This n=1 study, while preliminary, emphasizes the complex and individualized nature of lipid dynamics, where timing and type of intervention can significantly affect outcomes.
Fascinating findings that spark further discussion in the evolving field of lipid science!
Norwitz NG, Cromwell WC. Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment. Metabolites. 2024;14(1).
Comments