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Future of Aging Research

Jean-Marc Lemaitre's latest research delves into innovative approaches targeting cellular senescence and epigenetic alterations. Here’s the scoop:


  • Cellular Senescence: Cells under stress enter a permanent state of cycle arrest. This involves markers like increased ß-galactosidase activity and p16^INK4a induction. These senescent cells release the Senescence-Associated Secretory Phenotype (SASP), a mix of over 80 pro-inflammatory factors, including metalloproteinases, growth factors, chemokines, and cytokines. While SASP can aid in processes like wound healing and tumor suppression, it can also drive inflammation and aging.


  • Epigenetic Alterations: As we age, our cells’ ability to repair DNA diminishes, leading to epigenetic changes. This can result in apoptosis or cellular senescence. The good news? These alterations are largely reversible and can be influenced by our environment, like hormones or exercise.


  • Future Treatments: Promising strategies include:

o   Lifestyle Changes: Exercise and diet modifications.

o   Senolytic and Senomorphic Drugs: Clearing out senescent cells or modulating their secretome.

o   Cell Rejuvenation: Stimulating aged stem cells and reprogramming them.


With ongoing efforts, we’re on the brink of developing treatments to prevent or delay aging, and even rejuvenate tissues!  This could revolutionize how we age, promoting healthier, more vibrant lives.

 

Lemaitre, J.-M., Looking for the philosopher's stone: Emerging approaches to target the hallmarks of aging in the skin. Journal of the European Academy of Dermatology and Venereology, 2024. 38(S4): p. 5-14.




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