Redefining PCOS: A Metabolic Perspective on a Complex Disorder

Polycystic Ovary Syndrome (PCOS) affects millions of women worldwide, and its roots lie in metabolic dysfunction. Here’s how two major pathways drive PCOS and its symptoms:

🔑 1. Insulin Resistance:

• High insulin levels suppress aromatase, reducing the conversion of androgens to estrogens.

• This lowers estradiol levels, disrupting the LH surge needed for ovulation.

• The result? Irregular cycles, hyperandrogenism, and multiple ovarian cysts.

  
  

🔑 2. Neuroendocrine Imbalance:

• Increased GnRH pulsatility leads to excessive LH production, favoring androgen synthesis.

• Insufficient FSH levels impair follicle maturation, leaving immature follicles unable to ovulate.

  
  

💡 The result is a cycle of hormonal imbalance driven by metabolic dysfunction. PCOS isn’t just about fertility—it’s linked to insulin resistance, type 2 diabetes, and cardiovascular risks.

💪 Managing PCOS starts with addressing its metabolic roots—through lifestyle changes, targeted therapies, and early intervention. Let’s reshape the conversation about PCOS!

Helvaci, N., & Yildiz, B. O. (2024). Polycystic ovary syndrome as a metabolic disease. Nature Reviews Endocrinology. https://doi.org/10.1038/s41574-024-01057-w

#PCOSAwareness #MetabolicHealth #Women’sHealth #InsulinResistance