Dr. Dean Ornish's groundbreaking study explores the profound impact of intensive lifestyle changes on individuals with Mild Cognitive Impairment (MCI) or early dementia due to Alzheimer's Disease (AD). Conducted as a randomized, controlled clinical trial, this research delves into how specific lifestyle modifications can significantly improve cognitive function and overall well-being.
Impact of Lifestyle Changes:
Boost in Cognition: Comprehensive lifestyle changes may significantly improve cognition and function after 20 weeks in individuals with MCI or early dementia due to AD.
Biomarker Improvement: Lifestyle intervention improved cognitive function and the plasma Aβ42/40 ratio, with the microbiome improving in the intervention group.
Risk Factors: Unhealthful diets, sedentary behavior, emotional stress, and social isolation are linked to the onset and progression of dementia, including AD.
Lifestyle Changes Implemented in the Study:
Exercise:
Aerobic exercises such as walking for at least 30 minutes per day.
Mild strength training exercises at least three times per week.
Exercise sessions are overseen by an exercise physiologist either in person or through virtual sessions.
Personalized exercise prescriptions based on age and fitness level.
Stress Management:
Meditation, gentle yoga-based poses, stretching, progressive relaxation, breathing exercises, and imagery for one hour per day.
Option to use flashing-light glasses at a theta frequency of 7.83 Hz plus soothing music to aid meditation and insomnia.
Encouragement to get adequate sleep.
Group Support:
Participation in a support group for one hour/session, three days per week.
Aimed at increasing emotional support, community, communication skills, and strategies for program adherence.
Despite the challenges of a small sample size and limited diversity, the study's findings offer compelling evidence for the potential of holistic lifestyle interventions in slowing the progression of cognitive decline and enhancing the quality of life for those affected by AD.
Ornish, D., et al., Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial. Alzheimers Res Ther, 2024. 16(1): p. 122.
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