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Bridging the Metabolic Gap: The Connection Between Chronic Migraine and Alzheimer's Through Brain Energy Models

New research is bridging the gap between migraine and Alzheimer's disease through brain insulin resistance, highlighting the importance of maintaining metabolic flexibility for brain health.

Key Findings:

  • Meta-analysis confirms: Migraine sufferers have a higher risk of developing dementia, particularly Alzheimer's.

  • Both conditions share metabolic issues, especially brain insulin resistance and impaired glucose metabolism.

  • Brain insulin resistance can lead to energy deficits, promoting harmful changes such as protein misfolding that leads to amyloid plaques and tau tangles.

  • Similarities between chronic migraine and Alzheimer's include disrupted brain connectivity, grey matter loss, and increased neuroinflammation.

  • The proposed "Neuroenergetic Hypothesis" suggests a metabolic bridge between these conditions, highlighting the potential of alternative bioenergetic fuels to improve metabolic flexibility and brain health.

Potential Interventions:

  • Adopting a ketogenic or low-carb diet to enhance metabolic flexibility.

  • Regular aerobic exercise to boost insulin sensitivity.

  • ·Mind-body interventions to reduce stress and improve overall metabolism.


Understanding these metabolic mechanisms and sustaining long-term metabolic flexibility could help us better treat and prevent migraines and Alzheimer's!


Moro, L.D., E. Pirovano, and E. Rota, "Mind the Metabolic Gap: Bridging Migraine and Alzheimer's Disease Through Brain Insulin Resistance." Aging and Disease, 2024: p. 0-.


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