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From Fat to Forgetfulness: The Cognitive Toll of Obesity

Recent research reveals the incredible interplay between our body's adipose tissue (AT) and brain health.

Here’s a glimpse into the molecular mechanisms:


  • Synaptic Function & Inflammation: Genes in AT influence synaptic function and inflammation, key players in cognitive performance.

  • Diet Matters: A Western diet high in fats and sugars impacts gut health and the blood-brain barrier, leading to neurodegeneration and cognitive decline.

  • Brown Adipose Tissue: This special type of AT helps with thermogenesis and energy regulation, which is crucial for maintaining metabolic health.

  • Autophagy & Immune Regulation: Proper autophagy in AT is essential for balancing pro-inflammatory and anti-inflammatory macrophages, reducing chronic inflammation.

  • Nrf2 Pathway: Nrf2 regulates inflammation and glucose metabolism, keeping our cognitive functions sharp.

  • IL-25 & Lipid Metabolism: IL-25 boosts lipid uptake and lipolysis, preventing excess fat accumulation and supporting metabolic health.

  • Nlrp3 Inflammasome: This inflammasome responds to obesity-related stress, driving inflammation and insulin resistance, which can impact brain health.

Embrace a healthy lifestyle to support your body’s natural processes and keep your mind sharp!

Weijie, Z., et al., Obesity-induced chronic low-grade inflammation in adipose tissue: A pathway to Alzheimer’s disease. Ageing Research Reviews, 2024: p. 102402.


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