Exciting breakthrough: Researchers have developed PCAge, a next-generation biological aging clock with incredible precision to predict future health and longevity! 🧬✨
🔑 How does PCAge work?
Researchers applied Principal Component Analysis (PCA) to clinical data from thousands of participants, focusing on 165 measurable health parameters (like lab tests, body composition, and vital signs). They reduced these into key patterns, or "Principal Components (PCs)," that correlate with biological age and health outcomes.
💡 These PCs revealed critical insights into aging, highlighting metabolic, cardiac, and inflammatory pathways as central to healthy vs. unhealthy aging.
📊 The PCAge model was validated with 20+ years of data, outperforming traditional markers like chronological age (CA) or cardiovascular risk scores in predicting survival and age-related diseases.
🍎 Caloric Restriction Works!
In a groundbreaking study, moderate calorie restriction over two years significantly slowed biological aging. The PCAge-based custom clock (CALinAge) revealed that participants on calorie restriction aged at nearly zero biological years—proving that small, sustained changes can transform aging trajectories.
🩺 The simplified LinAge Clock makes this science actionable, tracking key markers like:🩸 Blood tests (glucose, CRP, cholesterol).
💓 Heart health (blood pressure, NT-proBNP).
⚖️ Body composition (BMI).
💡 These metrics are accessible through routine health check-ups, making monitoring your health and taking control of aging easier than ever.
💬 Ready to stay younger, longer? Follow these biomarkers, maintain a healthy lifestyle, and take charge of your future today! 🚀
Fong, S., Pabis, K., Latumalea, D., Dugersuren, N., Unfried, M., Tolwinski, N.,…Gruber, J. (2024). Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention. Nature Aging, 4(8), 1137-1152. https://doi.org/10.1038/s43587-024-00646-8
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