Did you know that SIRT1, a member of the sirtuin family of enzymes, is crucial in extending lifespan and promoting health? SIRT1 improves cellular functions, repairs DNA, and boosts metabolism. Studies show that overexpressing SIRT1 in yeast, worms, flies, and mice can significantly extend their lifespan!
How does it work?
SIRT1 deacetylates histones and over 50 non-histone proteins, regulating key processes like gene expression, stress resistance, and inflammation reduction. Resveratrol lowers the binding affinity of SIRT1 for substrates, enhancing its enzymatic activity.
One fascinating way to activate SIRT1 is through calorie restriction (CR). When we eat less (without malnutrition), SIRT1 activity increases, leading to longer, healthier lives. But here’s the exciting part: Resveratrol, a compound found in red wine, mimics the effects of CR! This powerful polyphenol activates SIRT1, improving health and extending lifespan in various species.
Rogina, B. and H.A. Tissenbaum, SIRT1, resveratrol and aging. Frontiers in Genetics, 2024. 15.
#HealthyAging #SIRT1 #Resveratrol #Longevity #MolecularBiology #CalorieRestriction #RedWineBenefits #Science
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