Aging isn't just about wrinkles—it's a symphony of molecular changes, and chronic inflammation plays a starring role. Scientists call this phenomenon "inflammaging"—a persistent, low-grade inflammation without infection, intertwined with the mechanisms of aging.
The Science Behind Inflammaging:
Genomic Instability: Damaged DNA due to reactive oxygen species triggers inflammatory responses, perpetuating cellular damage.
Mitochondrial Dysfunction: Aging mitochondria release danger signals like damaged mtDNA, sparking immune reactions.
Epigenetic Changes: Altered DNA methylation and histone modifications create a pro-inflammatory environment.
Senescence and Nutrient Sensing: Stressed cells secrete inflammatory molecules, while disrupted nutrient-sensing pathways like mTOR and AMPK exacerbate the cycle.
This feedback loop drives age-related diseases like cardiovascular issues, neurodegeneration, and cancer, making chronic inflammation both a cause and consequence of aging.
Why It Matters: Understanding these mechanisms helps researchers develop anti-aging interventions. From targeting inflammation to supporting mitochondrial health, molecular precision is the future of healthy aging.
Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023). Chronic inflammation and the hallmarks of aging. Mol Metab, 74, 101755. https://doi.org/https://doi.org/10.1016/j.molmet.2023.101755
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