Cumulative findings reveal a strong link between Alzheimer's Disease (AD) and Type 2 Diabetes (T2D), suggesting AD might be "Type 3 Diabetes" (T3D)!
Brain Health & Insulin Sensitivity:
Insulin isn't just about blood sugar! It's crucial for brain health, influencing memory and neuron function.
Insulin resistance, seen in T2D, can lead to brain insulin resistance, contributing to cognitive decline in AD.
Key Molecular Mechanisms:
Beta-Amyloid (Aβ) Toxicity: Insulin resistance boosts Aβ production, forming harmful plaques.
Tau Hyperphosphorylation: Insulin dysregulation activates pathways causing Tau protein tangles, damaging neurons.
Neuroinflammation & Oxidative Stress: Chronic inflammation and oxidative damage from insulin resistance accelerate neurodegeneration.
Vascular Issues: Shared vascular problems in T2D and AD further link these conditions.
Why It Matters:
Maintaining metabolic health and insulin sensitivity is crucial for preventing not just diabetes, but potentially AD too!
Therapies targeting insulin resistance or glucose control may offer new hope for AD patients.
Let's prioritize metabolic health for a healthier body and mind!
Peng, Y., et al., True or False? Alzheimer’s disease is Type 3 Diabetes: Evidences from Bench to Bedside. Ageing Research Reviews, 2024: p. 102383.
#Alzheimers #Type3Diabetes #MetabolicHealth #BrainHealth #InsulinSensitivity #NeuroScience #HealthyLiving #MedicalResearch

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