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Alzheimer's: The New Type 3 Diabetes?

Cumulative findings reveal a strong link between Alzheimer's Disease (AD) and Type 2 Diabetes (T2D), suggesting AD might be "Type 3 Diabetes" (T3D)!

 

Brain Health & Insulin Sensitivity:

  • Insulin isn't just about blood sugar! It's crucial for brain health, influencing memory and neuron function.

  • Insulin resistance, seen in T2D, can lead to brain insulin resistance, contributing to cognitive decline in AD.


Key Molecular Mechanisms:

  1. Beta-Amyloid (Aβ) Toxicity: Insulin resistance boosts Aβ production, forming harmful plaques.

  2. Tau Hyperphosphorylation: Insulin dysregulation activates pathways causing Tau protein tangles, damaging neurons.

  3. Neuroinflammation & Oxidative Stress: Chronic inflammation and oxidative damage from insulin resistance accelerate neurodegeneration.

  4. Vascular Issues: Shared vascular problems in T2D and AD further link these conditions.


Why It Matters:

  • Maintaining metabolic health and insulin sensitivity is crucial for preventing not just diabetes, but potentially AD too!

  • Therapies targeting insulin resistance or glucose control may offer new hope for AD patients.

Let's prioritize metabolic health for a healthier body and mind!


Peng, Y., et al., True or False? Alzheimer’s disease is Type 3 Diabetes: Evidences from Bench to Bedside. Ageing Research Reviews, 2024: p. 102383.

 



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