We’ve been looking at obesity all wrong. Osteosarcopenic Adiposity (OSA) isn’t just about excess fat—it’s about where that fat is stored. Fat infiltration into bones & muscles creates a metabolic disaster that fuels insulin resistance, type 2 diabetes, and cardiovascular disease. 🦴💪🔥
🔬 The Molecular Breakdown:
⚡ Fatty Muscle & Bone Marrow Adiposity → Infiltrated fat disrupts insulin signaling via inflammatory cytokines (TNF-α, IL-6), reducing glucose uptake.
⚡ Adipocyte Dysfunction → Hypertrophic fat cells resist insulin, release free fatty acids (FFAs), and drive chronic lipotoxicity & mitochondrial stress.
⚡ Ceramides & DAG Accumulation → Bioactive lipids block Akt/PKB, impairing insulin action and fueling metabolic dysfunction.
⚡ Extracellular Vesicles & miRNAs → Adipose-derived signals disrupt bone-muscle crosstalk, worsening osteoporosis & sarcopenia.
⚡ Fibrosis & Hypoxia → As adipose tissue expands, it triggers HIF-1α, VEGF, and chronic inflammation, further driving insulin resistance & muscle loss.
💡 Key Takeaway:
It’s not just about weight. Fat distribution and molecular signals shape metabolic health. Addressing muscle & bone health could be the missing link in reversing diabetes, obesity, and NCDs!
🔄 Actionable Steps:
🏋️♂️ Strength training to combat muscle & bone loss
🥑 Anti-inflammatory nutrition to reduce adipokine imbalances
🚶♀️ Movement to improve mitochondrial efficiency
Hu, K., Deya Edelen, E., Zhuo, W., Khan, A., Orbegoso, J., Greenfield, L.,…Kelly, O. J. (2023). Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition. Metabolites, 13(10), 1056. https://www.mdpi.com/2218-1989/13/10/1056
#OSA #MetabolicHealth #Diabetes #InsulinResistance #Mitochondria #MuscleHealth #BoneHealth #Inflammation #FatDistributionMatters

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