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Energy Triage as Key Contributor to Aging Phenotypes

An updated preprint discussed the Brain-Body Energy Conservation (BEC) model of aging, as a groundbreaking perspective on how our brain manages energy to influence the aging process.

Key Highlights:

  • Energy Broker: The brain acts as the central broker, balancing energy needs and availability.

  • Hypermetabolism: Aging cells trigger costly stress responses, leading to cellular hypermetabolism.

  • Brain's Role: The brain detects these signals and initiates energy-saving measures, impacting overall health and aging.

  • Systemic Effects: These responses can lead to muscle atrophy, cognitive decline, and other aging signs as the body conserves energy.

  • Adaptive Mechanisms: Some aging manifestations might be compensatory processes driven by the brain to manage accumulated damage.

This model not only explains how stressors accelerate aging but also sheds light on interventions that might slow down the aging process. Embracing bioenergetic principles could pave the way for holistic and effective health strategies in aging.


Shaulson, E. D., Cohen, A. A., & Picard, M. (2024). BEC model of aging.




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