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XWAS vs. GWAS: A Paradigm Shift in Aging Research
A major new study in Nature Medicine just dropped a game-changer : Your environment & lifestyle (exposome) play a MUCH bigger role in...
Feb 212 min read
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Cellular Survival or Self-Destruction? The Mitochondrial Stress Dilemma
Our mitochondria are stress sensors . When they’re under pressure, the Integrated Stress Response (ISRmt) kicks in to protect, repair,...
Feb 131 min read
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Inflammaging: The Drivers of Aging Hallmarks
Chronic inflammation, or " inflammaging ," is a major driver of the aging process and is linked to age-related diseases like heart...
Oct 2, 20241 min read
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Balancing Interleukin-6 in Liver Health: Too Much or Too Little
Intereukin-6 (IL-6) is crucial in liver health, acting through complex pathways. While IL-6 promotes liver regeneration via the...
Jul 11, 20241 min read
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Cellular Senescence Shapes Aging and Brain Function
Neuronal Senescence has a crucial impact on brain aging and neurodegenerative diseases. Senescent Cells have stopped dividing and show...
Jul 3, 20241 min read
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Cortisol and Hypermetabolism: Why Proper Nutrition Matters
An interesting study reveals that chronic stress triggers an energy-demanding process known as hypermetabolism. When our...
Jul 1, 20241 min read
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Mild Hyperhomocysteinemia Impacts Health Beyond Methylation
A recent study uncovers how even mild elevation of homocysteine (Hcy) significantly impacts cardiovascular health, extending beyond just...
Jun 8, 20241 min read
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Aging Brain: Interplaying between bone marrow aging, immunosenescence, and neuroinflammation
Our bone marrow and immune system undergo significant changes as we age, impacting our brain health. This fascinating mini-review by...
Jun 1, 20241 min read
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The Intricate Dance Between Epigenome and Metabolism
The relationship between the epigenome and metabolism plays a crucial role in human physiology, influencing cellular function and overall...
May 30, 20242 min read
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Energy Triage as Key Contributor to Aging Phenotypes
An updated preprint discussed the Brain-Body Energy Conservation (BEC) model of aging, as a groundbreaking perspective on how our brain...
May 23, 20241 min read
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Immunosenescence: Aging at Its Crossroads
As we age, our immune system declines, impacting B- and T-cell functions and causing chronic inflammation. A recent review by Snijckers &...
May 22, 20241 min read
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1.5. Integrated Stress Responses (ISR): The linchpin of chronic and age-related illnesses
The integrated stress response (ISR) is a complex biological response to a wide range of environmental and physiological challenges. In...
Feb 11, 20242 min read
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