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Mild Hyperhomocysteinemia Impacts Health Beyond Methylation

A recent study uncovers how even mild elevation of homocysteine (Hcy) significantly impacts cardiovascular health, extending beyond just methylation support.

Key findings reveal:


  • Oxidative Stress: Mild Hcy reduces Nrf2 protein content, crucial for antioxidant defense, and increases pro-oxidant DCF formation.

  • Inflammation: Elevated cytokines and altered TLR2 gene expression indicate a pro-inflammatory state, with increased NFκB content.

  • Cholinesterases Activity: Decreased acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities were observed, affecting cardiovascular function.


These insights highlight that even a mild elevation of homocysteine can play a significant role in cardiovascular disease, especially in aging populations.


Prauchner, G.R.K., et al., Mild hyperhomocysteinemia alters oxidative stress profile via Nrf2, inflammation and cholinesterases in the cardiovascular system of aged male rats. Chemico-Biological Interactions, 2024. 396: p. 111028.


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