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Cortisol and Hypermetabolism: Why Proper Nutrition Matters

An interesting study reveals that chronic stress triggers an energy-demanding process known as hypermetabolism. When our Hypothalamic-Pituitary-Adrenal (HPA) axis is activated, cortisol, a glucocorticoid (GC), leads to increased energy expenditure by ~60%. This metabolic shift moves from glycolysis to mitochondrial oxidative phosphorylation (OxPhos), causing our cells to age faster and wear out more quickly.


Chronic GC exposure results in mitochondrial DNA instability, shorter telomeres, and altered cytokine secretion. This stress-induced hypermetabolism accelerates cellular aging and reduces cell lifespan.


Key Takeaway: Supporting our diet with the right nutrients is essential to fuel our bodies and combat the effects of chronic stress. Providing the necessary nutrients for enhanced metabolism can help our cells survive daily challenges and promote overall health. Let's nourish our cells and thrive every day!


Bobba-Alves, N., et al., Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging. Psychoneuroendocrinology, 2023. 155: p. 106322.

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