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The Hidden Cost of Change: ISR & Energy Triage

Writer's picture: Torsak Tip-pairoteTorsak Tip-pairote

Every major change—whether in your body, cells, or life—costs energy. Just like moving to a new home requires time and resources, your cells need energy to transition between states. This is where the Integrated Stress Response (ISR) plays a critical role!


🔄 ISR: The Cell’s Energy Manager

When energy is abundant, ISR allows cells to differentiate, repair, and grow smoothly. But when energy is scarce, ISR activates an energy triage system, prioritizing essential survival functions and putting costly processes on hold.


🔥 The Energy Cost of Change

  • Cellular transitions—like differentiation or adaptation to stress—require high energy input.

  • If mitochondria struggle (e.g., oxidative phosphorylation defects), energy demand outpaces supply, forcing ISR to shut down nonessential functions.


⚠️ When Energy Runs Low

  • ISR halts growth & repair and redirects energy to survival.

  • Stress mitokines like GDF15 signal the brain to conserve energy & mobilize resources.

  • Chronic activation of ISR leads to hypermetabolism, inflammation, and accelerated aging.


💡 Takeaway:

Your body constantly balances energy demand and supply. Chronic stress and nutrient depletion push ISR into overdrive, diverting energy from long-term health (immune function, tissue repair) toward immediate survival.


🛠️ Optimize Your ISR:

✅ Support mitochondria with adequate macro



- and micronutrients

✅ Reduce chronic stress & inflammation

✅ Prioritize metabolic flexibility & recovery


Energy is life—use it wisely! ⚡✨


Monzel, A.S., M. Levin, and M. Picard, The energetics of cellular life transitions. Life Metabolism, 2023. 3(3).


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