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Ketogenic Metabolic Therapy Remit Depression and Anxiety

Recent Case series reveal that a personalized ketogenic diet can achieve complete remission of depression and anxiety! This groundbreaking case series shows that addressing metabolic health is crucial for treating psychiatric disorders.


  • Key Highlights:

    • Complete remission in 3 adults with major depression and generalized anxiety disorder within 7-12 weeks!

    • Significant improvements in metabolic health, including 10.9% to 14.8% weight loss and enhanced brain energy metabolism.

    • The ketogenic diet uses a 1.5:1 ratio of fat to protein and carbohydrates, providing optimal energy and metabolic support.

  • Potential Mechanisms:

    • Enhanced Brain Energy: Ketone bodies provide a more efficient and stable energy source for the brain, boosting cognitive function and mood.

    • Reduced Neuroinflammation: The ketogenic diet lowers inflammatory markers in the brain, crucial for mental health.

    • Mitochondrial Function: Improved mitochondrial efficiency supports better energy production and brain health.

    • Neurotransmitter Modulation: Ketones help balance neurotransmitters like GABA and glutamate, reducing symptoms of depression and anxiety.


Metabolic health plays a vital role in mental well-being. By sustaining the state of mild ketosis, we can improve brain function and mental health simultaneously!


Calabrese, L., R. Frase, and M. Ghaloo, Complete remission of depression and anxiety using a ketogenic diet: case series. Frontiers in Nutrition, 2024. 11.




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