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Inflammation: The Obesity-Brain Connection

Writer's picture: Healing_ PassionHealing_ Passion

Obesity impacts your waistline and triggers a cascade of inflammation that can affect your brain.


 Here's how:


  1. Chronic Inflammation: Obesity leads to chronic, low-grade inflammation, disrupting the communication between your body and brain.

  2. Blood-Brain Barrier: This inflammation increases the permeability of the blood-brain barrier, allowing harmful substances to affect brain function.

  3. Adipose Tissue: White adipose tissue (WAT) expands and becomes stressed, releasing pro-inflammatory signals through pathways like TLR4 and NF-κB.

  4. Leptin Resistance: High levels of leptin, meant to regulate appetite, become ineffective, promoting overeating and further weight gain.

  5. Cytokine Storm: Pro-inflammatory cytokines (TNF, IL-1β, IL-6, TGFβ) circulate, causing insulin resistance and damaging organs like the liver and pancreas.

  6. Microglial Activation: Inflammation activates microglia in the brain, contributing to cognitive impairments and increasing the risk of neurodegenerative diseases.


Understanding these molecular mechanisms can help us develop better interventions for obesity-related health issues. Stay informed, stay healthy!


Le Thuc, O., García-Cáceres, C. Obesity-induced inflammation: connecting the periphery to the brain. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01079-8

 



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